全文获取类型
收费全文 | 62778篇 |
免费 | 4251篇 |
国内免费 | 1601篇 |
专业分类
耳鼻咽喉 | 553篇 |
儿科学 | 1534篇 |
妇产科学 | 576篇 |
基础医学 | 5228篇 |
口腔科学 | 1617篇 |
临床医学 | 7336篇 |
内科学 | 8805篇 |
皮肤病学 | 1180篇 |
神经病学 | 8145篇 |
特种医学 | 4256篇 |
外科学 | 4341篇 |
综合类 | 9290篇 |
现状与发展 | 10篇 |
一般理论 | 4篇 |
预防医学 | 5931篇 |
眼科学 | 942篇 |
药学 | 4813篇 |
29篇 | |
中国医学 | 2207篇 |
肿瘤学 | 1833篇 |
出版年
2023年 | 906篇 |
2022年 | 1554篇 |
2021年 | 2331篇 |
2020年 | 2281篇 |
2019年 | 1785篇 |
2018年 | 1777篇 |
2017年 | 1878篇 |
2016年 | 2182篇 |
2015年 | 1900篇 |
2014年 | 3811篇 |
2013年 | 4120篇 |
2012年 | 3684篇 |
2011年 | 4009篇 |
2010年 | 3433篇 |
2009年 | 3328篇 |
2008年 | 3250篇 |
2007年 | 3198篇 |
2006年 | 2891篇 |
2005年 | 2638篇 |
2004年 | 2046篇 |
2003年 | 1834篇 |
2002年 | 1451篇 |
2001年 | 1469篇 |
2000年 | 1211篇 |
1999年 | 979篇 |
1998年 | 899篇 |
1997年 | 812篇 |
1996年 | 629篇 |
1995年 | 715篇 |
1994年 | 620篇 |
1993年 | 442篇 |
1992年 | 484篇 |
1991年 | 420篇 |
1990年 | 372篇 |
1989年 | 317篇 |
1988年 | 301篇 |
1987年 | 316篇 |
1986年 | 256篇 |
1985年 | 264篇 |
1984年 | 237篇 |
1983年 | 147篇 |
1982年 | 173篇 |
1981年 | 142篇 |
1980年 | 143篇 |
1979年 | 153篇 |
1978年 | 115篇 |
1977年 | 130篇 |
1976年 | 119篇 |
1975年 | 97篇 |
1973年 | 97篇 |
排序方式: 共有10000条查询结果,搜索用时 515 毫秒
61.
《Vaccine》2022,40(19):2679-2695
Vaccinations are essential for preventing infectious diseases in children with chronic diseases as they have increased risk of infection from frequent use of biologics. Response to immunizations in this group is not well known.ObjectiveA systematic review was performed to evaluate three primary outcomes: efficacy; immunogenicity; and safety of vaccines in children with chronic conditions treated with biologics.MethodsThe protocol for our systematic review and meta-analysis was registered and published with PROSPERO. We searched electronic bibliographic databases for studies published from 2009 to 2019, focusing on vaccinations in children with chronic conditions treated with biologics.ResultsWe retrieved 532 records. Thirty-one full-text articles were selected, and 14 were included in the meta-analysis. No significant publication bias was found. Efficacy: limited data are available regarding the efficacy of vaccination, as most studies have focused on immunogenicity as surrogate outcome for efficacy. Immunogenicity: patients receiving anti-TNF-alpha therapy had a statistically significant risk of poor seroconversion (p = 0.028) and seroprotection by the serotype B influenza vaccine [inflammatory bowel disease (IBD) p = 0.013; juvenile idiopathic arthritis (JIA) p = 0.004]. We found adequate responses with H1N1 and H3N2 serotypes. Few studies existed for pneumococcal, hepatitis A virus, hepatitis B virus, varicella-zoster virus, Measles Mumps Rubella virus, and multiple vaccine administration. Safety: vaccine administration was not associated with serious side effects, but JIA patients on anti-TNF alpha therapy had a statistically significant risk of presenting with myalgia or arthralgia postinfluenza vaccine (p = 0.014).ConclusionsMore evidence concerning efficacy, immunogenicity, and safety of vaccinations is needed to guide physicians in the vaccine decision process for this pediatric population. 相似文献
62.
63.
64.
急性脑梗死是威胁我国人民健康的重大疾病,其致死率及致残率均较高,造成了沉重的社会负担。及时开通导致梗死的责任血管以恢复脑灌注是治疗该病的关键。机械取栓技术的应用使得患者的血栓组织能够被获取并得到研究。本文介绍了近年来通过机械取栓术获取的血栓的相关研究发现,以纤维蛋白为主的血栓是造成取栓困难的重要组织学原因,影像学方法可以在术前评估血栓特征。这些发现提示临床工作者可以积极开发新型血栓取出装置用于处理难治性血栓,并有必要探索精确便捷的血栓特征影像学评价方法,从而提高机械取栓疗效。 相似文献
65.
《Clinical breast cancer》2022,22(7):629-633
Metastatic HER2-positive (HER2+) and triple-negative breast cancer (TNBC) confer a 30% or higher risk of developing brain metastases (BrM), but BrM is typically an exclusion criteria for clinical trials, which limits the generalizability of trial results to these patients. We therefore analysed trends in the enrollment of patients with BrM, as well as the use of outcomes specific to the central nervous system (CNS), in phase III clinical trials evaluating systemic therapy for patients with advanced HER2+ and/or TNBC. Notably, 10 of the 34 trials (29%, 95% confidence interval = 15.1%-47.5%) evaluated CNS-specific outcomes and trials that completely excluded patients with BrM were significantly less likely to meet their primary endpoint (n = 6/17, 35%) than those that permitted conditional enrollment (n = 13/15, 87%) (P = .005), suggesting that enrollment of patients with BrM is not detrimental to trial success. 相似文献
66.
Tsvetelina Velikova 《World Journal of Immunology》2022,12(2):9-14
To control the pandemic, efficient vaccines must be applied to the population, including patients with autoimmune diseases. Therefore, one can expect that coronavirus disease 2019 (COVID-19) vaccines may influence the underlying autoimmune processes in these patients. Additionally, it is essential to understand whether COVID-19 vaccines would be effective, safe, and provide long-lasting immunological protection and memory. However, the currently available and approved COVID-19 vaccines turned out to be safe, effective, and reliable in patients with autoimmune inflammatory and rheumatic diseases. Furthermore, most patients said they felt safer after getting vaccinations for COVID-19 and reported enhanced overall quality of life and psychological wellbeing. In general, the COVID-19 vaccines have been highly tolerated by autoimmune patients. Such findings might comfort patients who are reluctant to use COVID-19 vaccines and assist doctors in guiding their patients into receiving vaccinations more easily and quickly. 相似文献
67.
长期以来的研究表明先天免疫和后天免疫在宿主抵御外来微生物入侵的过程中起着至关重要的作用,而在这过程中也会同时造成宿主自身的组织或器官的损害。骨骼系统就是其中之一,在一些诸如类风湿性关节炎、牙周炎等疾病中,免疫系统的反应不仅起到去除外来致病菌的作用,还会同时造成骨骼系统的破坏。长期以来大部分的研究都致力于了解免疫系统对骨组织破坏的机制,而近些年来有研究开始探究骨反作用于免疫系统,由此衍生出了一个全新的研究领域——骨免疫。文章从骨免疫的机制、免疫与骨吸收作用通路以及在口腔相关疾病的作用机制等方面总结了近些年来相关的研究进展。 相似文献
68.
姚峰 《中国工业医学杂志》2022,35(2):191-191